News item posted on 2013-01-11

Sanders & Iverson/Gurevich Labs Collaborate on Arrestin Paper

The Sanders Lab and the Iverson/Gurevich Lab have jointly published the paper, "Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin," in the Proceedings of the National Academy of Science, USA.

The project was led by Tiandi Zhuang, postdoc student in the Sanders Lab, and Qiuyan Chen, graduate student in the Iverson/Gurevich Lab and VISP/Pharmacology graduate programs.

The paper includes the first ever NMR spectra of an arrestin bound to a full-length G protein-coupled receptor. It also suggests the nature of the structural change that takes place in the arrestin when it becomes activated to stimulate intracellular signaling upon binding to active and phosphorylated receptors.

The paper is currently available online and will be available in print soon. Read the entire paper at PNAS.

Author: Karen D. Davis